The coverage report is generated with cacao version 1.0.0, using the following key settings:
- Genome assembly: grch37
- Mode: Hereditary cancer AND actionable somatic loci AND somatic hotspots
- Alignment quality threshold (MAPQ): 0
- Callability levels (somatic):
-
NO_COVERAGE: No coverage (zero sequencing depth)
-
LOW_COVERAGE: Sequencing depth from 1 to 29
-
CALLABLE: Sequencing depth from 30 to 199
-
HIGH_COVERAGE: Sequencing depth above 200
- Callability levels (germline):
-
NO_COVERAGE: No coverage (zero sequencing depth)
-
LOW_COVERAGE: Sequencing depth from 1 to 9
-
CALLABLE: Sequencing depth from 10 to 99
-
HIGH_COVERAGE: Sequencing depth above 100
Hereditary cancer - known pathogenic loci
Global distribution

Actionable loci - somatic mutations
Global distribution

Cancer hotspots
Global distribution
